Why mirror neurons do not exist

Peter MolemanArticles, Parts and the whole, The world within your head2 Comments

Translated by Rumia Bose

I want to get myself an apple and take a juicy bite. My brain is abuzz with activity, including in the premotor cortex, which is the region where actions – such as getting myself an apple – are prepared for. Then I see somebody else take an apple and – wonder of wonders – my premotor cortex is just as active. In monkeys you can see the activity occurring in exactly the same neuron as when it is about to take an apple itself1. That is strange, because my watching someone else take an apple has nothing to do with my own motor action when taking an apple. Why does my premotor cortex react the same way although I am not performing the action?

The discovery of mirror neurons

The term mirror neuron was coined by the researchers who discovered this phenomenon. The monkey or human imitates the action in their brain even without performing the actual deed, in thoughts as it were. In this way they can understand the function of the activity for the other. And this comprehension goes further, as the researchers claimed. They found, for example, neurons which are active when a person is disgusted, but also when observing disgust in another person. Therefore mirror neurons also play a role in understanding another’s emotions. Taking this a step further. the mirror neurons supposedly have a function in empathy. Meanwhile, mirror neurons were also discovered in other brain areas. Which was logical when their role seemed to have expanded to include functions where brain areas outside of the premotor cortex were involved. While investigating the connections of these neurons the experimenters found a network of neurons with mirroring properties. In this connection they now refer to the mirror system. This research was considered one of the greatest discoveries of the century and led to a hype around mirror neurons. The New York Times: “Cells that read minds”, Scientific American: “What makes humans social” and Ramachandran’s TED talk “Mirror neurons do for psychology what DNA did for biology”.

Doubts

Following this, large numbers of researchers in other laboratories also investigated this phenomenon and found various characteristics of mirror neurons. Thousands of publications have followed. But there were also critical notes right from the start. They address various methodological aspects which detract from the far-reaching conclusions. Most researchers do not dispute the fact that the act of observing an action by another activates the same neuronal circuits that are also active when carrying out the same or similar action oneself. But whether this has to do with mirroring remains the question.

Embodied simulation

The way I see it, there is nothing special about the activation of the same neurons in the premotor cortex when preparing for one’s own action and while observing another performing the same action. This is in fact a rather common phenomenon in the brain. When I recall something, then the same neurons in my visual, auditory and other brain areas are activated as during the actual event. See “Remembering an event changes your memory“. When I imagine something then I see that with my mind’s eye. Then too the same neurons in visual areas are activated as when actually seeing the scene. See “Seeing with your mind’s eye: not for everyone“.
Humans -and other animals: primates, apes and more? – are capable of imagining their own and others’ behaviour and to simulate these in thought without actually performing the actions. The physical aspects – seeing or moving – can be simulated with the help of the brain areas which are also involved in the actual activities. This is known as embodied simulation, and does not require any special neurons.

Neurons do not correspond to one specific function

But my main issue with mirror neurons is much more basic. The point being that there are no neurons which are associated one-on-one with a function. In the primary visual cortex you have neurons which react to vertical lines but not to horizontal lines2. That is a simple function. But if you destroy that neuron, then another neuron reacts to a vertical line and the function is maintained. And on the other hand, there is no neuron which only reacts to lines which are precisely vertical. And this is definitely the case as regards more complicated functions. Which is why researchers these days do not study the activity of single neurons but the activity of networks of neurons. The activity of a single neuron says nothing about the higher function.

The function of parts and the whole

The relation between neurons and higher functions can also be explained in a different way. Neurons are brain cells, which are basic elements of which the brain is constituted. The functions of the brain, including the higher functions, arise from the basic elements. But there is nothing of the higher function to be found in the activities of the basic elements3. Therefore there is no mirroring to be found in the activity of neurons. That might be better understood by the following analogy. Starlings sometimes form large flocks. These arise and maintain formation in motion by individuals following certain rules of keeping distance between themselves and their neighbours. In these rules and the behaviour of the starlings there is nothing to be found about the dynamics and movements of the flock as a whole. See “Who directs the brain?” for a video and more detailed explanation.

Mirror neurons: the mereological fallacy

If you think that a neuron mirrors, as it were, the behaviour of another animal or “mirror neuron systems in the human brain help us understand the actions and intentions of other people”4 then you have fallen prey to the mereological fallacy5: attributing a property of the whole to the parts. As if a starling in the flock were to be seen as a special sort of starling: a “flock starling”. There is no such thing as a mirror neuron or the mirror system, just as there is no Jennifer Aniston neuron or neurons for a particular emotion or a particular movement.

References

Bekkali S, Youssef GJ, Donaldson PH, Albein-Urios N, Hyde C, Enticott PG (2020): Is the Putative Mirror Neuron System Associated with Empathy? A Systematic Review and Meta-Analysis. Neuropsychol Rev DOI: 10.1007/s11065-020-09452-6

Heyes C, Catmur C (2020): What happened to mirror neurons? PsyArXiv DOI: 10.31234/osf.io/dtnqg

Saxena S, Cunningham JP (2019): Towards the neural population doctrine. Curr Opin Neurobiol 55:103–111.

Buzsáki G (2019): The Brain from Inside Out. Oxford University Press. ISBN 978-0-19-090540-8, p. 27, p. 98, p. 127, p. 182.

Thompson EL, Bird G, Catmur C (2019): Conceptualizing and testing action understanding. Neuroscience & Biobehavioral Reviews 105:106–114.

Calabrese RL (2018): Inconvenient Truth to Principle of Neuroscience. Trends in Neurosciences 41:488–491.

Churchland PS (2018): Braintrust: what neuroscience tells us about morality. Princeton University Press. Kindle Edition (ISBN 978-0-691-18097-7)

Campbell ME, Cunnington R (2017): More than an imitation game: Top-down modulation of the human mirror system. Neurosci Biobehav Rev 75:195–202.

Del Pinal G, Nathan MJ (2017): Two Kinds of Reverse Inference in Cognitive Neuroscience in : The Human Sciences after the Decade of the Brain. Elsevier, pp 121–139. ISBN 978-0-12-804205-2

Koban L, Ramamoorthy A, Konvalinka I (2017): Why Do We Fall into Sync with Others? Interpersonal Synchronization and the Brain’s Optimization. PrincipleSoc Neurosci DOI: 10.1080/17470919.2017.1400463

Fusi S, Miller EK, Rigotti M (2016): Why neurons mix: high dimensionality for higher cognition. Current Opinion in Neurobiology 37:66–74.

Veldhuizen R (2016): Hoe serieus moeten we spiegelneuronen nemen? KIJK Magazine 7:33–36.

Hasson U, Frith CD (2016): Mirroring and beyond: coupled dynamics as a generalized framework for modelling social interactions. Philos Trans R Soc Lond B Biol Sci 371. DOI: 10.1098/rstb.2015.0366

Rizzolatti G, Sinigaglia C (2016): The mirror mechanism: a basic principle of brain function. Nat Rev Neurosci 17:757–765.

Catmur C (2015): Understanding intentions from actions: Direct perception, inference, and the roles of mirror and mentalizing systems. Consciousness and Cognition 36:426–433.

Decety J (2015): The neural pathways, development and functions of empathy. Current Opinion in Behavioral Sciences 3:1–6.

Hagoort P (2014): Spiegelneuronenmythologie en de Beppe Grillo van de neurowetenschap: https://taalenhersenen.wordpress.com/2014/10/18/spiegelneuronenmythologie-en-de-beppe-grillo-van-de-neurowetenschap/

Hickok G (2014): The Myth of Mirror Neurons. NY, W.W. Norton & Company. ISBN 978-0-393-08961-5

Molnar-Szakacs I, Uddin LQ (2013): Self-processing and the default mode network: interactions with the mirror neuron system. Front Hum Neurosci 7. DOI: 10.3389/fnhum.2013.00571

Hamilton AF de C (2013): Reflecting on the mirror neuron system in autism: A systematic review of current theories. Dev Cogn Neurosci 3:91–105

Rizzolatti G, Sinigaglia C (2010): The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations. Nat Rev Neurosci 11:264–74.

Prinz AA, Bucher D, Marder E (2004): Similar network activity from disparate circuit parameters. Nature Neuroscience 7:1345–1352.

Bennett, M.R. and Hacker, P.M.S. (2003). Philosophical Foundations of Neuroscience. Blackwell Publishing. ISBN 978-1-4051-0838-6, p. 68.

Ryle, G. (1949 (2009)). The Concept of Mind; 60th anniversary edition, Routledge. ISBN 0-203-87585-0.

Footnotes
  1. This can be demonstrated using electrodes which measure the electrical activity of a single neuron in the premotor cortex of that monkey. We cannot repeat such experiments in humans but it is very likely that the same thing occurs.
  2. The work for which Hubel and Wiesel won the Nobel prize a long time ago
  3. A neuron, though computationally complex, is just a neuron. It is not an intelligent homunculus. If a neural network represents something complex, such as the intention to insult, it must have the right input and be in the right place in the neural circuitry to do that. Churchland, Patricia S.. Braintrust: (p. 142). See references
  4. See https://en.wikipedia.org/wiki/Mirror_neuron
  5. See The Ego is dead, long live the ego

2 Comments on “Why mirror neurons do not exist”

  1. This is great! Maybe it’s the way the information is digested in news and popular books I’ve read, but I rarely have seen neuroscience pieces with this conceptual nuance and clarity.

  2. I am rereading Andy Clark’s “Surfing uncertainty” (Clark A (2016): Surfing uncertainty : prediction, action, and the embodied mind. New York, Oxford University Press. eISBN 978–0–19–021703–7), Ch. 5.6:
    “It may be, however, that the existence of mirror neurons is more of a symptom than an explanation, and that flexible, context-sensitive, predictive processing provides a more fundamental mechanism. “

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