DNA Archives - Brein in Action

Obesity is 60% heritable. And this means …

Peter Moleman29/06/2021Articles, Genes and heredityLeave a Comment

The mass media report percentages of heritability. for various conditions. For instance autism is 90% heritable, height 80%, BMI 60%, musical aptitude 50%, depression 40%, breast cancer 30%. But these percentages are of no use to you, because they only apply to the population investigated, not in general. And they vary immensely between populations. Telling someone that their trait or illness has a specific heritability percentage is wrong.

Families, genes, and psychiatric disorders

Peter Moleman10/06/2021Articles, Genes and heredity, PsychiatryLeave a Comment

Genetic variants and mutations can increase the susceptibility to psychiatric disorders. But the DSM does not really apply to the real world of genetically determined presentations. Hospital departments for DSM categories are outdated. Clusters of families would make better units for research into and care for severe mental disorders.

Can you inherit homosexuality?

Peter Moleman31/05/2021Articles, Brain development, Genes and heredityLeave a Comment

I can still remember the commotion which arose in 1990 when Dutch neuroscientist Dick Swaab published an article saying that homosexual men had an area in their hypothalamus which was twice the size of the same area in heterosexual men. Many found the idea – that homosexuality might have a biological basis – quite alarming! At the time I worked … Read More

Autism is hereditary, but you don’t inherit autism

Peter Moleman13/02/2020Articles, Genes and heredity, Psychiatry2 Comments

Autisme is erfelijk, maar je erft geen autisme | Peter Moleman

The probability of having autism is greater for an individual if it runs in their family. This suggests hereditary factors. But what do you actually inherit? What you inherit is a predisposition for a specific development of your brain. This, together with what you experience while growing up, can lead to the development of a mild to severe form of autism.

The parable of the murderous brain

Peter Moleman17/10/2019Articles, Parts and the wholeLeave a Comment

De parabel van het brein dat een moord pleegde | Peter Moleman

In a country with golden sand dunes by the sea, each year saw more murders committed than the year before. Neuroscientists had proven that the murderer’s brain made him commit the murder. The judges were stuck. How could they solve this problem?

The new crystal ball: predicting future disease

Peter Moleman03/10/2019Articles, Genes and heredity, PsychiatryLeave a Comment

Disease can be seen as the antechamber of death.
Are there reliable tests for predicting disease? The short answer is: not for Alzheimer’s or other common diseases. Tests do exist for some specific diseases, most with known familial predispositions, such as Huntington’s disease, cystic fibrosis, Duchenne’s dystrophy and many more.

Nature and nurture: congenital and acquired

Peter Moleman18/01/2018Articles, Genes and heredityLeave a Comment

Nature en nurture; aangeboren en aangeleerd | Peter Moleman

Is it Nature or Nurture, congenital or acquired? The answer is actually quite simple: everything is Nature and Nurture. The structure of the brain determines what we can learn and what we learn determines the structure of the brain.