A lot of people think antidepressants are worthless. Is psychotherapy better than an antidepressant? There is no evidence for this. It seems to me that antidepressants suffer a disadvantage in our perception as compared to psychotherapy, in that their mechanism of action is quite invisible and not instinctively comprehensible.
The placebo effect doesn’t exist
Depression lifts with placebo pills, joint pain disappears after a placebo operation. Changes in the brain can be observed after the use of a placebo. How do such effects of sham treatment come about? Placebos do have effects. But THE placebo effect does not exist.