Psilocybin and meditation can have a huge impact on our predictive organ. This can make a new person of you, provided it is used the right way.
A lot of people think antidepressants are worthless. Is psychotherapy better than an antidepressant? There is no evidence for this. It seems to me that antidepressants suffer a disadvantage in our perception as compared to psychotherapy, in that their mechanism of action is quite invisible and not instinctively comprehensible.